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3 Things I Learned About Intermittent Fasting

See my story about how I went from thinking intermittent fasting was impossible to making it a routine habit. What I learned Intermittent Fasting is Not Hard The Body Adapts It Gave Me Confidence The health benefits of intermittent fasting are outlined in this article from the New England Journal of Medicine. https://www.nejm.org/doi/full/10.1056/NEJMra1905136

By |2023-12-17T00:23:51+00:00July 26th, 2023|Kidney Disease|0 Comments

Metabolic Alkalosis

This article will address: Diagnosis of metabolic alkalosis and assessment of compensation. Approach to differential diagnosis/ underlying cause of metabolic alkalosis. Metabolic Alkalosis Diagnosis Elevated pH (>7.42) Elevated serum HCO3- (>26) Elevated pCO2 (compensation) What you will initially see (either in the hospital or outpatient setting) is an elevated serum HCO3.  This can

By |2023-12-17T00:28:43+00:00July 19th, 2023|Kidney Disease|0 Comments

MPGN Membranoproliferative Glomerulonephritis

MPGN is not a specific disease, it is a pattern of injury seen on light microscopy of kidney biopsy. Membrano - Diffuse thickening of glomerular capillary walls Proliferative - Increased number of cells in the glomeruli Therefore MPGN is when glomeruli have both thickened capillary walls and an increased number of cells. This

By |2023-12-17T00:36:36+00:00July 5th, 2023|Kidney Disease|0 Comments

Metabolic Acidosis – Approach to Diagnosis

You’ve evaluated an acid base disorder. You diagnosed a metabolic acidosis: pH: Low Serum Bicarbonate (HCO3): Low pC02: Low How do you figure out what caused it?  This article will provide a framework for differential diagnosis - looking at the: Anion Gap - Is it elevated? Delta - Delta - What’s that? Osmolar

By |2023-12-17T00:43:47+00:00June 28th, 2023|Kidney Disease|0 Comments

IgA Nephropathy

IgA Nephropathy may be the most common glomerulonephritis (GN)  in the world.  It is most common in East Asians (Chinese and Japanese), relatively common in Caucasians and relatively rare in people of African descent. IgA nephropathy can have a wide range of presentations with variable prognosis. This article will discuss: Clinical presentations Prognosis

By |2023-12-20T01:29:39+00:00June 14th, 2023|Kidney Disease|0 Comments

Nephrotoxicity from Chemotherapy

Nephrotoxicity from Chemotherapy There are many different mechanisms of nephrotoxicity from chemotherapeutic drugs.  These include indirect and direct renal toxicity. Indirect mechanisms Prerenal AKI due to hypovolemia from chemo induced nausea, vomiting, and diarrhea Ischemic acute tubular necrosis (ATN) from neutropenic sepsis or cytokine release syndrome (seen in CAR-T therapy) Direct mechanisms Nephrotoxic

By |2023-12-20T01:32:53+00:00June 7th, 2023|Kidney Disease|0 Comments

Membranous Nephropathy

Membranous nephropathy is an important cause of nephrotic syndrome in adults. This condition is exciting in nephrology because the pathogenic antibody for the majority of cases of primary idiopathic membranous nephropathy has been discovered.  This is the phospholipase A2 receptor (PLA2R) antibody. Clinical Presentation Often presents as full blown nephrotic syndrome with severe

By |2023-12-23T21:32:13+00:00May 24th, 2023|Kidney Disease|0 Comments

Fractional Excretion of Sodium: The Importance of Trusting Your Gut

Two parts of trusting your gut: If something doesn’t make sense it probably isn’t right. Take a step back and look again. Don’t go along with something you don’t believe. What is the FeNa? The FeNa is the percent of sodium filtered by the kidneys (glomeruli) that is excreted in the urine. What

By |2023-12-23T21:35:35+00:00May 17th, 2023|Kidney Disease|0 Comments

FSGS – Focal Segmental Glomerulosclerosis

FSGS is a pathologic description meaning a part (segment) of some of the glomeruli (focal) are scarred (sclerosis).  Since scarring is the end result of most glomerular injury, anything that is severe enough for long enough will end up causing sclerosis. It’s like minimal change disease, but worse.  It is a more common

By |2024-02-28T15:12:38+00:00May 3rd, 2023|Kidney Disease|0 Comments

Understanding Acid Base Disorders

This is a topic that is often given as a reason by students and residents for choosing a nephrology elective, wanting to understand acid base disorders. There are multiple ways to assess acid base status. Physiologic Approach Base Excess Approach Stewart Method Nephrologists use the Physiologic approach. What is this? There is an

By |2023-12-23T21:42:57+00:00April 26th, 2023|Kidney Disease|0 Comments
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