There are certain dermatologic conditions unique to ESRD that the nephrology practitioner should be aware of. These include: Uremic pruritus Calciphylaxis - calcific uremic arteriolopathy Perforating Dermatosis - Kyrle Disease Nephrogenic Systemic Fibrosis Uremic Pruritus Pruritus is a common complaint in ESRD. It may be localized or generalized. Pathogenesis. It is often attributed
When writing this article I felt a need to add more and more information, to be comprehensive. I had a fear of leaving something out. I need to stop. The intention of BCNephro is not to be an encyclopedic nephrology resource. The intention is to share my experiences in a way that makes
What is glomerulonephritis? Glomerulonephritis is inflammation of the glomerulus. This is may be manifest by: Clinical Findings: Glomerular hematuria Variable proteinuria (typically sub nephrotic may be nephrotic) Leukocyturia (variable) Impaired kidney function (variable) Hypertension (variable) May be renal limited or associated with systemic inflammation (vasculitis) Pathologic Findings: Glomerular hypercellularity Crescents (indicate more severe
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Amyloidosis is another relatively common systemic condition that causes nephrotic syndrome with unique kidney pathology. Approximately 2% of native kidney biopsies will show amyloidosis. What is amyloidosis? Amyloidosis is a syndrome where proteins deposit in tissues in a specific misfolded pattern forming what is called beta pleated sheets. These protein deposits result in
Diabetic kidney disease is the most common cause of kidney failure. 20-40% of diabetics get diabetic kidney disease. It typically occurs after 5 years of diabetes. Remember that the true duration of diabetes is often not known in patients with type 2 as the patient may have had the condition undiagnosed for a
See my story about how I went from thinking intermittent fasting was impossible to making it a routine habit. What I learned Intermittent Fasting is Not Hard The Body Adapts It Gave Me Confidence The health benefits of intermittent fasting are outlined in this article from the New England Journal of Medicine. https://www.nejm.org/doi/full/10.1056/NEJMra1905136
This article will address: Diagnosis of metabolic alkalosis and assessment of compensation. Approach to differential diagnosis/ underlying cause of metabolic alkalosis. Metabolic Alkalosis Diagnosis Elevated pH (>7.42) Elevated serum HCO3- (>26) Elevated pCO2 (compensation) What you will initially see (either in the hospital or outpatient setting) is an elevated serum HCO3. This can
MPGN is not a specific disease, it is a pattern of injury seen on light microscopy of kidney biopsy. Membrano - Diffuse thickening of glomerular capillary walls Proliferative - Increased number of cells in the glomeruli Therefore MPGN is when glomeruli have both thickened capillary walls and an increased number of cells. This
You’ve evaluated an acid base disorder. You diagnosed a metabolic acidosis: pH: Low Serum Bicarbonate (HCO3): Low pC02: Low How do you figure out what caused it? This article will provide a framework for differential diagnosis - looking at the: Anion Gap - Is it elevated? Delta - Delta - What’s that? Osmolar
