What is rhabdomyolysis? Rhabdomyolysis is a condition where there is muscle necrosis with release of intracellular muscle contents into the systemic circulation. Most notably: CK (creatine kinase): detected in blood Myoglobin: detected in urine Others AST/ALT If severe: Potassium, Phosphorus, Urate, Lactic acid In rhabdomyolysis the CK is markedly elevated. When is the
Treatment of Kidney Stones. Once we know or deduce the type of kidney stone, the next focus is treatment. In a patient with recurrent nephrolithiasis, treatment is secondary prevention. That is prevention of stone growth or new stone forming. Acute stones that are passing are typically managed by urology as they may require
Kidney stones are common and the incidence is increasing. Knowledge of management and prevention is imperative. This article will approach diagnosis. Not diagnosing that a patient has a kidney stone, but diagnosing the type of stone and assessing for secondary causes in patients with recurrent nephrolithiasis. Types of Kidney Stones The five most
Interstitial Nephritis is an important cause of Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD). This article will talk about Acute Interstitial nephritis (AIN) AIN may be difficult to diagnose. AIN is relatively common. 1 study found that 12.9% of renal biopsies for AKI showed interstitial nephritis. AIN may cause severe AKI
Which patients with kidney disease should be screened for monoclonal gammopathy? Assessment for paraproteins is important for the evaluation of most kidney diseases. Paraproteins can be associated with a wide spectrum of renal manifestations including: Acute Kidney Injury Chronic Kidney Disease Proteinuria +/- Nephrotic syndrome Proximal Tubulopathies (i.e. Fanconi syndrome) Patients should be
Why Calculate Creatinine Clearance? Creatinine clearance is an estimate of Glomerular Filtration Rate (GFR). It is a useful estimate of GFR because: Creatinine is produced by the body in relatively stable amounts Creatinine is eliminated by the kidneys. The majority of this renal clearance is by glomerular filtration, a small amount is eliminated
What happens if you only have one kidney? Causes of a Solitary Kidney First, what are the reasons that someone would have only one kidney? These can be broken down to congenital or acquired. Congenital Some are born with only one or one functional kidney. This can be because: The kidney never formed
Renin Angiotensin System (RAS) blockers are renoprotective and often used in chronic kidney disease (CKD). RAS blockers include: Angiotensin Converting Enzyme (ACE) Inhibitors Angiotensin Receptor Blockers (ARB) These medications have proven benefits in proteinuric CKD Proteinuria: What is it and How I Treat | BCNephro , including microalbuminuria in patients with diabetic kidney
This article will provide a framework for evaluation of the patient with abnormal kidney function (elevated serum creatinine/ decreased estimated Glomerular Filtration Rate (eGFR). When evaluating a patient with Chronic Kidney Disease (CKD), I have the following considerations: Is there something bad? Is it chronic? What is the underlying cause? Is There Something
The main test to indicate kidney function is the serum creatinine. Why is this? First, what are we talking about when we talk about kidney function? We’re talking about how well the kidneys filter the blood. This is the glomerular filtration rate (GFR). Creatinine is a marker for kidney function because it is
