BCNephro Logo

BCNephro

Home|BCNephro

About BCNephro

This author has not yet filled in any details.
So far BCNephro has created 85 blog entries.

Sodium What is Normal? 140 vs 154

A normal sodium on a lab test is 140 mEq (or mmol) / liter, but normal saline (which is purportedly isotonic to plasma) is 154 mEq/liter. What gives? This article will describe how sodium is measured clinically and explain this apparent discrepancy. How Sodium is Measured Historically sodium was measured by flame photometry,

By |2024-12-26T13:25:32+00:00December 26th, 2024|Kidney Disease|0 Comments

Primary Hyperaldosteronism

Primary hyperaldosteronism is the most common modifiable cause of secondary hypertension with an estimated prevalence as high as 20%. This article will review normal aldosterone secretion and oversecretion, indications for screening, how to screen and confirm the diagnosis. Normal Aldosterone Secretion and Mechanism of Action Secreted by the zona glomerulosa of the adrenal

By |2024-12-16T14:09:18+00:00December 16th, 2024|Kidney Disease|0 Comments

Overview of Peritoneal Dialysis

The definition of dialysis is: “the separation of particles in a liquid on the basis of differences in their ability to pass through a membrane”. Clinically dialysis requires: Access to blood A semipermeable membrane Dialysis solution Particles (urea, creatinine, other uremic molecules and electrolytes) diffuse between blood and dialysate down the concentration gradient.

By |2024-12-08T19:46:15+00:00November 26th, 2024|Dialysis|0 Comments

How I Improved Sleep

Sleep has always been important to me, not because of any specific health benefit.  I just don’t like being tired.  It turns out sleep has important health benefits too.  Not the least of which is an association with living longer and healthier. How sleep helps prevent chronic disease | Peter Attia, M.D. Over the past

By |2024-11-15T19:43:46+00:00November 15th, 2024|Healthy Living|0 Comments

Lipid Lowering Agents and the Kidney

Many, if not most patients with chronic kidney disease (CKD) will have indications and benefit from pharmacologic treatment of hyperlipidemia.  Despite this patients and some clinicians may have concerns about nephrotoxicity with use of these medications. This article will review the data regarding renal safety and the potential for adverse renal effects of

By |2024-10-31T12:56:58+00:00October 31st, 2024|Kidney Disease|0 Comments

Medication Induced Hypertension – Abiraterone

What Is Abiraterone? Abiraterone (Zytiga) is a medication used in the treatment of metastatic prostate cancer. It works by decreasing the production of androgens in the testes, adrenal glands and the prostate tumor (androgen deprivation therapy). Abiraterone inhibits the enzyme Cytochrome P450 C17A1 (CYP17A1).  This enzyme has two functions: 17𝝰-hydroxylase 17,20 lyase Inhibition

By |2024-10-09T13:12:17+00:00October 9th, 2024|Hypertension|0 Comments

Alport Syndrome

Alport syndrome is the most common inherited kidney disease, more prevalent than autosomal dominant polycystic kidney disease (ADPKD). Awareness of this condition, particularly the autosomal recessive and autosomal dominant variants, has increased as genetic testing has become mainstream. What is Alport syndrome? Alport syndrome is a genetic condition with an abnormality of type

By |2024-09-25T15:38:04+00:00September 25th, 2024|Kidney Disease|0 Comments

Creatinine and Creatine – What’s the difference?

Creatine and creatinine sound similar, similar enough that patients may mistake them.  And then there’s creatinine kinase (CK) or creatinine phosphokinase (CPK).  If you’ve wondered what the difference is you're in luck - read on. Creatine Creatine is a molecule composed of 3 amino acids: glycine, arginine, and methionine. 90% of creatine is

By |2024-09-11T12:14:41+00:00September 11th, 2024|Dialysis, Kidney Disease|0 Comments

Use of Bisphosphonates and Denosumab in Kidney Disease

Bisphosphonates and denosumab are anti resorptive medications used for the treatment of: Osteoporosis Hypercalcemia, especially hypercalcemia of malignancy Hypercalcemia, Nephrology and the Milk Alkali Syndrome @BCNephro Hypercalcemia BCNephro Malignancy, particularly multiple myeloma and bone metastasis with solid tumors (prostate, breast, lung) Both classes of medications exert their anti resorptive effects by inhibiting osteoclast

By |2024-09-11T12:19:17+00:00September 4th, 2024|Kidney Disease|0 Comments
Go to Top