Amyloidosis is another relatively common systemic condition that causes nephrotic syndrome with unique kidney pathology. Approximately 2% of native kidney biopsies will show amyloidosis. What is amyloidosis? Amyloidosis is a syndrome where proteins deposit in tissues in a specific misfolded pattern forming what is called beta pleated sheets. These protein deposits result in
Hypercalcemia is of interest to both nephrologists and endocrinologists. Why nephrology? Hypercalcemia may cause acute kidney injury (AKI) Hypercalcemia, in specific primary hyperparathyroidism, is associated with nephrolithiasis (kidney stones). Secondary and Tertiary hyperparathyroidism is a complication of chronic kidney disease (CKD) and end stage renal disease (ESRD) primarily managed by nephrologists. Bottom line:
Mineral bone disease in dialysis patients refers to assessment and management of Phosphorus, Calcium, and Parathyroid Hormone (PTH) Pathophysiology The kidney normally is responsible for excretion of phosphorus and conversion of inactive - 25- hydroxyvitamin D to active - 1,25-hydroxyvitamin D via the enzyme 1 alpha-hydroxylase. Therefore with kidney failure there is: Impaired
Diabetic kidney disease is the most common cause of kidney failure. 20-40% of diabetics get diabetic kidney disease. It typically occurs after 5 years of diabetes. Remember that the true duration of diabetes is often not known in patients with type 2 as the patient may have had the condition undiagnosed for a
